abstract：:MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cell...

authors： Lessi F,Aretini P,Rizzo M,Morelli M,Menicagli M,Franceschi S,Mazzanti CM

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Concerns are increasing about the clinical characteristics of gram- negative bacterial peritonitis for providing reference for clinical diagnosis, treatment and prevention. METHODS:A retrospective analysis was performed examining patients who developed peritoneal dialysis-related peritonitis (PDRP) from 1 J...

authors： Zeng Y,Jiang L,Lu Y,Wang Z,Song K,Shen H,Feng S

更新日期：2021-12-01 00:00:00

abstract：:Shigella is an intracellular pathogen that primarily infects the human colon and causes shigellosis. Shigella virulence relies largely on the type III secretion system (T3SS) and secreted effectors. VirF, the master Shigella virulence regulator, is essential for the expression of T3SS-related genes. In this study, we ...

authors： Li W,Jiang L,Liu X,Guo R,Ma S,Wang J,Ma S,Li S,Li H

更新日期：2021-12-01 00:00:00

abstract：:Due to the important role of N6-methyladenosine (m6A) in breast cancer, single nucleotide polymorphisms (SNPs) in genes with m6A modification may also be involved in breast cancer pathogenesis. In this study, we used a public genome-wide association study dataset to identify m6A-SNPs associated with breast cancer and ...

authors： Xuan Z,Zhang Y,Jiang J,Zheng X,Hu X,Yang X,Shao Y,Zhang G,Huang P

更新日期：2021-12-01 00:00:00

abstract：:Outbreaks of highly pathogenic strains of avian influenza (HPAI) cause high mortality in avian populations worldwide. When spread from avian reservoirs to humans, HPAI infections cause mortality in about 50% of human infections. Cases of human-to-human transmission of HPAI are relatively rare, and have, to date, only ...

authors： Tripathi A,Dhakal HC,Adhikari K,Chandra Timsina R,Wahl LM

更新日期：2021-12-01 00:00:00

abstract：:Quercetin-loaded nanosuspensions (Que-NSps) added metabolic inhibitors were evaluated as drug delivery system to promote the oral bioavailability of quercetin. Que-NSps were prepared respectively using d-alpha tocopherol acid polyethylene glycol succinate (TPGS) or Soybean Lecithin (SPC) as stabilizer. On the basis, P...

authors： Li H,Li M,Fu J,Ao H,Wang W,Wang X

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Although abnormal cerebrospinal fluid (CSF) protein can be used to predict the outcome of tuberculous meningitis (TBM) and diagnose TBM, normal CSF protein remains a concern in patients with TBM. This retrospective study aimed to assess the clinical characteristics associated with normal CSF protein, to reso...

authors： Wang JL,Han C,Yang FL,Wang MS,He Y

更新日期：2021-12-01 00:00:00

abstract：:The objective of this paper is to confine piperine, a poor oral bioavailable herbal drug into bile salt based nano vesicles for improving its aqueous solubility, hence, its therapeutic activity. Piperine-loaded bilosomes were fabricated adopting thin film hydration technique according to 32.21 full factorial design to...

authors： Zakaria MY,Fayad E,Althobaiti F,Zaki I,Abu Almaaty AH

更新日期：2021-12-01 00:00:00

abstract：:In Spain, human transmissible spongiform encephalopathies (TSEs) have been undergoing continuous surveillance for over 25 years. In 1995, the system was launched as an EU Concerted Action, with EU surveillance network procedures being incorporated from 2002 onwards. The aim of this report was to describe performance a...

authors： De Pedro-Cuesta J,Almazán-Isla J,Tejedor-Romero L,Ruiz-Tovar M,Avellanal F,Rábano A,Calero M,García López FJ,Spanish CJD Surveillance Group.

更新日期：2021-12-01 00:00:00

abstract：:Despite many advances in medical education, medical students continue to mostly shadow on inpatient rotations like Neurology. They seldom receive face-to-face feedback or mentorship from attending physicians. This results from not training attending physicians how to integrate medical students into clinical activities...

authors： Edwardson MA

更新日期：2021-12-01 00:00:00

abstract：:Physical rehabilitation and psychosocial support are a part of cancer patients well-being and their ability to cope. Physical geography and healthcare provider barriers may have negative influences on patients' health outcomes. To explore the perceptions and experiences of cancer rehabilitation in a rural area in nort...

authors： Björnsdóttir EB,Hjörleifsdóttir E,Sigurðardóttir Þ,Baruchello G,Þormóðsson FR

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:To explore the efficacy and short-term complications of a modified technique to percutaneously insert a peritoneal dialysis catheter. METHODS:We reviewed the outcomes of 94 patients who underwent peritoneal dialysis catheterization between October 2017 and April 2020. Of these, 47 cases were placed by a conv...

authors： Zou Y,Ma Y,Chao W,Zhou H,Zong Y,Yang M

更新日期：2021-12-01 00:00:00

abstract：:In this study, we show that BNT162b2 vaccine-elicited antibodies efficiently neutralize SARS-CoV-2 authentic viruses belonging to B.1, B.1.1.7, B.1.351, B.1.525 and P.1 lineages. Interestingly, the neutralization of B.1.1.7 and B.1.525 lineages was significantly higher, whereas the neutralization of B.1.351 and P.1 li...

authors： Zani A,Caccuri F,Messali S,Bonfanti C,Caruso A

更新日期：2021-12-01 00:00:00

abstract：:Plants can produce cellular metal nanoparticles (NPs) from the uptake of metal ions, but the mechanism remains unclear. This work reported the new insight into different fates of iron (Fe) and nickel (Ni) ions to transform into the metal NPs in Azolla pinnata roots. After exposing to ferric nitrate, nickel nitrate, an...

authors： Janthima R,Siri S

更新日期：2021-12-01 00:00:00

abstract：:The present study examined how resveratrol affects cell growth and MAGEA12/Akt signaling pathway in OSCC cells. Cal-27 cells were transiently transfected with a plasmid encoding MAGEA12, and the effects of overexpression were assessed in terms of cell viability, colony formation and the epithelial-mesenchymal transiti...

authors： Shang Y,Jiang YL,Ye LJ,Chen LN,Ke Y

更新日期：2021-12-01 00:00:00

abstract：:Exposure to mercury (Hg) is a global concern, particularly among Arctic populations that rely on the consumption of marine mammals and fish which are the main route of Hg exposure for Arctic populations.The MercuNorth project was created to establish baseline Hg levels across several Arctic regions during the period p...

authors： Adlard B,Lemire M,Bonefeld-Jørgensen EC,Long M,Ólafsdóttir K,Odland JO,Rautio A,Myllynen P,Sandanger TM,Dudarev AA,Bergdahl IA,Wennberg M,Berner J,Ayotte P

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the diagnostic performance of an autoantibody battery in patients receiving immune checkpoint inhibitors who experienced immune-related adverse events (irAEs). METHODS:We retrospectively analyzed several variables potentially related to irAEs, namely, demographic, clinica...

authors： Les I,Martínez M,Narro A,Pérez I,Sánchez C,Puntí L,Anaut P,Eguiluz S,Herrera A,Domínguez S

更新日期：2021-12-01 00:00:00

abstract：:Background: Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome characterized by high blood pressure and vascular remodeling in the pulmonary arterioles, which is also a rapidly progressing disease of the lung vasculature with a poor prognosis. Although PAH medication made great advances in r...

authors： Fu W,He W,Li Y,Chen Y,Liang J,Lei H,Fu L,Chen Y,Ren N,Jiang Q,Shen Y,Ma R,Wang T,Wang X,Zhang N,Xiao D,Liu C

更新日期：2021-12-01 00:00:00

abstract：:Chromosomes are the carriers of inheritable traits and define cell function and development. This is not only based on the linear DNA sequence of chromosomes but also on the additional molecular information they are associated with, including the transcription machinery, histone modifications, and their three-dimensio...

authors： Di Stefano M,Nützmann HW

更新日期：2021-12-01 00:00:00

abstract：:The ongoing COVID-19 pandemic has led to more than 159 million confirmed cases with over 3.3 million deaths worldwide, but it remains mystery why most infected individuals (∼98%) were asymptomatic or only experienced mild illness. The same mystery applies to the deadly 1918 H1N1 influenza pandemic, which has puzzled t...

authors： Jiang X,Tan M,Xia M,Huang P,Kennedy MA

更新日期：2021-12-01 00:00:00

abstract：:Chronic pancreatitis (CP) is a progressive inflammatory disease. In clinical treatment, many patients cannot get a timely diagnosis and effective treatment due to the lack of early diagnosis indicators. Mesenchymal stem cells have immunomodulatory and anti-inflammatory effects, and have broad application prospects in ...

authors： Kong L,Xu X,Zhang H,Zhou Y,Huang H,Chen B,Zhou Z

更新日期：2021-12-01 00:00:00

abstract：:The effective delivery system plays an important role in the application of siRNA in the antitumor study. However, until now, researches on the delivery systems targeting hepatocarcinoma cells are still being explored. Here we designed and prepared a novel siRNA delivery system, cRGD-PSH-NP, which was based on a modif...

authors： Yang S,Wang D,Zhang X,Sun Y,Zheng B

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:To determine the incidence of invasive Group B streptococcal (iGBS) diseases and the factors significantly associated with iGBS mortality in adult patients. MATERIAL AND METHODS:This retrospective study included adults with a positive culture for GBS isolated from a sterile site at Siriraj Hospital - Thaila...

authors： Phoompoung P,Pirogard N,Leelaporn A,Angkasekwinai N

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:The coriander plant Centipeda minima (L.) A. Braun et Aschers (Compositae) is used for the treatment of allergic rhinitis. OBJECTIVE:Analyze the difference of the C. minima volatile oil from 7 geographic areas and its therapeutic effect on allergic rhinitis. MATERIALS AND METHODS:The volatile oils from differ...

authors： Jia Y,Zou J,Wang Y,Zhang X,Shi Y,Liang Y,Guo D,Yang M

更新日期：2021-12-01 00:00:00

abstract：:Purpose: Anabolic androgenic steroids (AAS) are used by men for their aesthetic and performance-enhancing effects and are associated with risk for side effects. Our research aims to deepen knowledge and understanding of men´s experiences of using AAS.Method: This phenomenological study is based on the reflective lifew...

authors： Börjesson A,Ekebergh M,Dahl ML,Ekström L,Lehtihet M,Vicente V

更新日期：2021-12-01 00:00:00

abstract：:The authors analyse descriptions of Greenlandic and Faroese medicine found in an Italian medical publication from the 18th century entitled, Europae Medicina a Sapientibus Illustrata […], which was printed in Brescia, in Northern Italy, in 1747. The author of these descriptions, Francesco Roncalli Parolino (1692-1769)...

authors： Porro A,Falconi B,Lorusso L,Franchini AF

更新日期：2021-12-01 00:00:00

abstract：:A novel compound 1 and nine known compounds (2-10) were isolated by open column chromatography analysis of the root bark of Ulmus davidiana. Pure compounds (1-10) were tested in vitro to determine the inhibitory activity of the catalytic reaction of soluble epoxide hydrolase (sEH). Compounds 1, 2, 4, 6-8, and 10 had I...

authors： Kim JH,Park JS,Lee YJ,Choi S,Kim YH,Yang SY

更新日期：2021-12-01 00:00:00

abstract：:Zinc oxide nanoparticles (ZnO-NPs) have been produced by physical and chemical methods. Here, the comparative evaluation of both chemically-synthesised ZnO-NPs (C-ZNPs) and in-vitro cultured S. marianum mediated green-synthesised ZnO-NPs (G-ZNPs) were investigated on seed germination frequency, root and shoot growth, ...

authors： Saeed F,Younas M,Fazal H,Mushtaq S,Rahman FU,Shah M,Anjum S,Ahmad N,Ali M,Hano C,Abbasi BH

更新日期：2021-12-01 00:00:00

abstract：:Ferroptosis, a newly discovered iron-dependent form of cell death, contributes to various pathologies; however, the prognostic value of ferroptosis-related genes (FRGs) in cervical cancer (CC) remains unclear. Herein, we identified 15 differentially expressed FRGs based on data from The Cancer Genome Atlas database. T...

authors： Qi X,Fu Y,Sheng J,Zhang M,Zhang M,Wang Y,Li G

更新日期：2021-12-01 00:00:00

abstract：:Living at high latitudes is associated with vitamin D (VD) deficiency. An ideal setting to study this is the Antarctic continent, which has temporary inhabitants, but the magnitude of the effect of living in Antarctica and the effects of VD supplementation on this population remain unclear. We performed a systematic r...

authors： Cabalín C,Iturriaga C,Pérez-Mateluna G,Echeverría D,Camargo CA Jr,Borzutzky A

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Signs of the systemic inflammatory response syndrome (SIRS) - fever (or hypothermia), tachycardia and tachypnoea - are used in the hospital setting to identify patients with possible sepsis. OBJECTIVES:To determine how frequently abnormalities in the vital signs of SIRS are present in adult out-of-hours (OO...

authors： Loots FJ,Smulders D,Giesen P,Hopstaken RM,Smits M

更新日期：2021-12-01 00:00:00

abstract：:Oxaliplatin resistance is one of the main causes of failed colorectal cancer treatment, followed by recurrence and metastasis. In this study, we found that colorectal cancer cells secrete a high level of hyaluronic acid (HA), which interacts with its receptor CD44v6 to mediate colorectal cancer resistance to chemother...

authors： Du W,Yang X,He S,Wang J,Guo Y,Kou B,Jiang Y,Bian P,Li B,Yin L

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Acute myeloid leukaemia (AML) is a haematopoietic malignancy with a dismal outcome. Consequently, risk stratification based on more effective prognostic biomarkers is crucial to make accurate therapy decisions. T cell receptor gamma alternative reading frame protein (TARP) has been reported in prostate and b...

authors： Shi Y,He Z,Bei L,Tao H,Ding B,Tao S,Wang C,Yu L

更新日期：2021-12-01 00:00:00

abstract：:Reports of school and work absences due to unmet menstrual needs have prompted increased attention to menstruation in policy and practice. However, there appear to be few quantitative studies reported in published literature capturing the prevalence of this hypothesised absenteeism. This study undertook secondary anal...

authors： Hennegan J,OlaOlorun FM,Oumarou S,Alzouma S,Guiella G,Omoluabi E,Schwab KJ

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP) variability is highly correlated with cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD). However, appropriate BP targets in patients with CKD remain uncertain. METHODS:We searched PubMed, Embase, and the Cochrane Library for randomized controlled trials (RC...

authors： Zhang Y,Li JJ,Wang AJ,Wang B,Hu SL,Zhang H,Li T,Tuo YH

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Achyranthes bidentata Blume (Amaranthaceae) (ABR) and semen vaccariae (SV) are used commonly in the clinical treatment of erectile dysfunction in males with diabetes mellitus (DMED) to strengthen the kidney and promote blood circulation, and often achieve good curative effects. OBJECTIVE:Explore mechanistic de...

authors： Wang JS,Feng JL,Dai HH,Chen ZL,Li X,Bao BH,Deng S,Meng FC,Zhao Q,Xu HS,Wang B,Li HS

更新日期：2021-12-01 00:00:00

abstract：:The aim of this study was to build up a novel chiral mesoporous silica called PEIs@TA-CMS through a facile biomimetic strategy and to explore its potential to serve as a drug carrier for improving the delivery efficiency of poorly water-soluble drug. PEIs@TA-CMS was synthesized by using a chiral crystalline complex as...

authors： Xin W,Wang Y,Bian Y,Lin J,Weng W,Zhao X,Gou K,Guo X,Li H

更新日期：2021-12-01 00:00:00

abstract：:The use of recorded video in medical education is increasing. Video material may be assigned before scheduled sessions to create a flipped classroom. Here, the instructor may lead a session that is organized for discussion, interpretation, and reflection of the previewed content. We established conditions that lead to...

authors： Bordes SJ,Walker D,Modica LJ,Buckland J,Sobering AK

更新日期：2021-12-01 00:00:00

abstract：:Purpose: This study investigated whether the mini-clinical evaluation exercise (mini-CEX) has been successfully integrated into the Chinese context, following its introduction as part of the national general training programme. Materials and methods: Online questionnaires (N = 91) and interviews (N = 22) were conducte...

authors： Liang Y,Noble LM

更新日期：2021-12-01 00:00:00

abstract：:The scope of teleaudiology has been noted with telehealth due to Coronavirus disease (COVID-19) recently. As the notion has been around us for more than 20 years ever since 1999, it is necessary to perceive the knowledge accurately and prepare for the successful implementation of it. Therefore, the literature review i...

authors： Kim J,Jeon S,Kim D,Shin Y

更新日期：2021-12-01 00:00:00